The field of neuroplacentology is a growing area that focuses on the influence of placental function on brain development. This field has expanded our understanding of the placenta's crucial role in proper neurodevelopment as well as placental anomalies that increase the risk of adverse neurodevelopmental outcomes. Neuroplacentology studies have revealed distinct roles of placentally provided hormones and nutrients in neurodevelopment whose disruption by perinatal problems, including...

CONCLUSIONS: Impaired value-based decision-making is dimensionally associated with greater NSSI engagement, with reduced punishment-based learning and choice persistence emerging as preliminary cognitive markers. With further research, these computational targets may eventually inform early identification and intervention efforts.

CONCLUSIONS: Gambling problems are often hidden within behavioral health ED presentations. The ED might provide a novel setting for detecting gambling disorder and gambling-related suicidality among patients with urgent behavioral health concerns.

CONCLUSION: In a population with a cigarette smoking history, lung function decline and CT measurements were associated with prospective frailty risk.

CONCLUSION: Marital stability buffers against AUD problems across the lifespan. However, the risks associated with marital instability are highly specific: marital exit poses a critical threat in early mid-life, while widowhood represents a profound vulnerability for older men. Interventions should be tailored with attention to life stage and sex-specific risks to mitigate alcohol-related harm during marital transitions.

CONCLUSIONS: Quantity and type of genetic risk are important for AUD outcomes. EXT plays an outsized role in AUD, particularly in the presence of other high PGS, and may potentiate alcohol expectancies that reinforce harmful patterns of use. Findings elucidate the role of multiple pathways of genetic risk for AUD and how they impact comorbid phenotypes.

CONCLUSIONS: Older Veterans access virtual GMH care for a wide range of mental health and cognitive disorders. The apparent higher utilization of psychotherapy and dementia services for rural compared with non-rural Veterans may relate to barriers to obtaining these services locally, although it may be partially explained by variations in virtual team compositions and settings served.

Spaceflight presents unique challenges to ocular health, with astronauts experiencing a range of visual disturbances in the setting of microgravity, radiation exposure, and other environmental factors. This review synthesizes knowledge about how spaceflight affects ocular anatomy and function. We outline the diagnostic and therapeutic limitations in microgravity, including constraints on imaging modalities, intracranial pressure measurement, and drug delivery. In addition, we examine common...

CONCLUSIONS: Results from this study may inform future implementation and administrative investigations of pregnant and postpartum veterans' use of chiropractic, CIH, and Whole Health services.

CONCLUSIONS: NPS increase in prevalence and co-occurrence over 10 years in biomarker-positive, sporadic PD. Time-varying symptom groupings and persistent low- and high-NPS burden phenotypes further highlight the progressive and heterogeneous nature of NPS evolution in PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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High rates of comorbid posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) may stem from a shared neurobiological basis; however, research exploring this overlap remains limited. We examined whole-brain structural covariance (SC) across PTSD, AUD, comorbid PTSD & AUD, trauma-exposed controls, and trauma-naïve controls to identify shared and unique SC profiles. Structural brain scans were acquired from individuals across 14 sites (N = 1565), and cortical thickness estimates were...

CONCLUSIONS: In NSSI adolescents, sleep-associated glymphatic upregulation reflects a stress-induced compensatory response. This mechanism domain-specifically preserves high-load affective decision-making against severe psychopathological stress. These findings highlight brain metabolic clearance as a novel physiological target for bolstering cognitive resilience in high-risk youth.

Reinforcement learning (RL) models describe how reward computations shape our choices, but whether the same computations also shape memory in the human brain is unclear. To address this question, we combined multi-areal intracranial recordings with computational modeling of reward and memory in neurosurgical patients. Patients played a gambling task in which decisions yielded monetary rewards tied to trial-unique images, followed immediately by a recognition test for those images. Model-derived...

CONCLUSIONS: VSP training improved provider fidelity in delivering SPI and may represent a scalable strategy for disseminating evidence-based suicide prevention practices across healthcare systems.