CONCLUSIONS: Single-session interventions may be one helpful approach among a menu of stepped care options in primary care. Future work will benefit from ongoing exploration of the most appropriate processes for implementation of single-session interventions in primary care.

Fathers play a crucial role in their children's psychosocial development, positively influencing emotional, cognitive, and social competencies. Paternal Post-Traumatic Stress Disorder (PTSD) can disrupt this dynamic, potentially compromising the psychological well-being and developmental outcomes of their offspring. This systematic review aims to investigate the relationship between paternal PTSD and the prevalence of psychopathology in children and adolescents, providing a comprehensive...

16p11.2 microduplication (16p11.2^(dp/+)) is associated with neuropsychiatric disorders including schizophrenia, autism and intellectual disability. Cerebellar abnormalities have been implicated in these disorders. In 16p11.2^(dp/+) mice, the cerebellum displays significant transcriptional dysregulation, and humans with 16p11.2 microduplication have decreased cerebellar volume. Despite this, cerebellar anatomy and cerebellar-dependent behaviour in 16p11.2^(dp/+) mice remain uncharacterized. To...

Although skilled readers make use of information about words adjacent to the fixated word, developing readers are known to be limited in their uptake of parafoveal information, leading to the expectation that they may be entirely insensitive to the presence of adjacent stimuli. However, lack of benefit from nearby items does not imply that those items cannot negatively impact the recognition process. Here we report two experiments with 62 Norwegian children attending Grade 2 and 141 in Grade 5...

Adolescence is a sensitive neurodevelopmental period marked by remodeling of brain circuits that support cognitive development and emotion and behavior regulation. These maturation processes heighten psychiatric vulnerability to environmental exposures, including to toxicants such as insecticides. Epidemiological studies show widespread adolescent insecticide exposure and increasingly link this with psychiatric outcomes, yet underlying neural mechanisms remain poorly understood. Preclinical...

Delirium is a common yet underdiagnosed condition in elderly hospitalized patients. The lack of effective diagnostic and therapeutic methods can be attributed to the limited understanding of its pathophysiology. Delirium has recently been reported to be linked to neuroinflammation and epigenetic changes. The aim of this study was to validate the pathways in a larger cohort with a uniform type of surgery, while rigorously adjusting for potential covariates. This study primarily investigated DNA...

To better understand the earliest stages of alpha-synucleinopathy, the Parkinson's Progression Markers Initiative (PPMI) has enrolled participants prior to the diagnosis of Parkinson's disease (PD) or dementia with Lewy Bodies (DLB). In this review, we describe lessons learned from prior enrollment and current strategies for PPMI eligibility. Severe hyposmia remains the strongest clinical predictor of aggregated synuclein as measured by a positive cerebrospinal fluid alpha-synuclein seed...

Electrical signalling across distinct populations of brain cells underpins cognitive and emotional function. However, approaches that selectively regulate electrical signalling between two cellular components of a mammalian neural circuit remain sparse. Here we engineered an electrical synapse composed of two connexin proteins¹ found in Morone americana (white perch fish)-connexin 34.7 and connexin 35-to accomplish mammalian circuit modulation. By exploiting protein mutagenesis, devising a new...

The creation and ongoing development of the myPPMI platform (see Stanley et al in this issue), has enabled the Parkinson's Progression Markers Initiative (PPMI) to expand our research efforts to acquire additional data, engage a large number of participants, and reduce participant burden to enable long-term follow-up. We now review specific virtual and remote studies and sub-studies including Found, PPMI Online, and PPMI Cognitive that PPMI has developed to enhance participant engagement and...

CONCLUSION: Suicide attempt may be linked to heightened feedback sensitivity to environmental contingencies, greater decision-making randomness and higher rumination. Moreover, the role of both forgetfulness and deck perseverance in trauma survivors at risk for suicide needs to be further investigated to refine their cognitive profile.

Photometry and electrophysiology are powerful tools for investigating brain-behavior relationships. Combining these techniques in freely moving animals would allow us to ask questions such as how neuromodulators impact neuronal firing rates during behavior. Current options are limited-requiring a substantial loss in data quality or restricting naturalistic movement. These drawbacks arise from engineering limits on devices that allow optically tethered subjects to move freely. Here we introduce a...

BACKGROUND: Patients with extensive ischaemic change are often excluded from endovascular thrombectomy. We aimed to synthesise the evidence from recent trials in these patients by performing a systematic review and individual patient data meta-analysis to estimate treatment benefit, including within clinical and imaging subgroups.

Transcranial magnetic stimulation (TMS) is a widely used neuromodulation treatment for depression, but its mechanisms are poorly understood. Indirect clinical evidence suggests that TMS enhances plasticity within the prefrontal cortical target site and engages downstream networks. However, establishing causal mechanisms to help optimize the large stimulation parameter space has been challenging. Using an optogenetic model of accelerated intermittent theta burst stimulation (prelimbic [PL]-aiTBS)...

Mild traumatic brain injury (mTBI) often leads to migraine-like post-traumatic headache (PTH), yet effective treatments are limited. Clinical and preclinical studies have shown that mTBI disrupts glymphatic transport of cerebrospinal fluid in the brain. We hypothesized that altered glymphatic transport might underlie facial allodynia commonly associated with migraine and PTH. A closed-head impact model was used to induce mTBI in mice. Facial allodynia, a symptom of PTH and migraine, was...

CONCLUSIONS: This early report highlights the value of a human-centered, iterative process for adapting therapeutic materials for digital delivery in SUD treatment. Although the modules performed well overall on PEMAT-P benchmarks, actionability was less consistent than understandability, and aggregate scores masked weaknesses in several individual modules. This indicates that a standardized process does not guarantee actionable material across all content types. Involving current patients in...