Background: Cervical artery dissection (CeAD) may result in dissecting aneurysm (DA) formation. We aimed to characterize risk factors and clinical outcomes associated with DA in a large, international CeAD cohort. Methods: We performed a secondary analysis of the Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection (STOP-CAD), an international, multicenter, retrospective cohort. Patients with spontaneous CeAD were assessed for DA at baseline and de novo DA formation....

Background/Objectives: Obesity and insulin resistance (IR) increase the risk of mood disorders, which often manifest during young adulthood. However, neuroelectrophysiological investigations of whether adiposity and IR modify electrocortical activity and emotional processing outcomes remain underexplored, particularly in young adults. Therefore, this study used electroencephalography (EEG) to investigate whether obesity and/or IR moderate the relationships between brain potentials and affective...

CONCLUSIONS: Accordingly, this study indicates a strong effect of chronic HAC, but not short-term HAC, on mortality, further highlights the limitations of self-reported alcohol use in the prediction of all-cause mortality and indicates the value of assessing HAC in addition to smoking.

CONCLUSIONS: At baseline, SAA- sPD PPMI participants have a substantially lower rate of hyposmia, but otherwise cannot be readily distinguished from SAA+ participants based on clinical characteristics. However, SAA- participants have a greater degree of subcortical brain atrophy, and approximately one out of seven SAA- participants received a change in diagnosis. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder...

In this commentary on 'Annual Research Review: Early conduct problems - precursors, outcomes, and etiology' by Hyde and colleagues, I discuss the strengths of that review and its heuristic value in inspiring future research directions. The review is an impressive, comprehensive, scholarly, and up-to-date broad summary of the current state of developmental science related to conduct problems. By embracing biopsychosocial/ecological perspective and reviewing constructs and processes across...

OBJECTIVE: Despite being safe and effective, surgery for pediatric epilepsy is underutilized. Social determinants of health (SDoH) are important to consider when examining this treatment gap. This study examined the potential systemic inequities at three different stages in the journey toward epilepsy surgery across the Pediatric Epilepsy Research Consortium (PERC).

Self-regulation is the basic capacity to regulate one's thoughts, emotions, and behaviors. The aim of the present study is to examine the psychometric properties of the Self-Regulation Scale (SRS) among male and female Portuguese youth participants (N = 559 youth, M = 16.51 years, SD = 1.07, range = 14-20 years). The three-factor model composed of the Emotional, Cognitive, and Behavioral regulation subscales obtained adequate fit, although the fit of the second-order model was also acceptable....

CONCLUSIONS: Our findings strengthen the psychometric evidence supporting this novel measure of oppression-based traumatic stress, an important step in furthering intersectional research on this topic. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Persistent vulnerability to drug-seeking is driven by enduring synaptic adaptations, yet current μ-opioid receptor-targeting pharmacotherapies provide limited efficacy against these neuroadaptations. Thus, there is a critical need for mechanistically distinct, non-opioid interventions. We recently found that carbonic anhydrase 4 (CA4) disruption reduces cocaine-induced synaptic adaptations and drug-seeking. Building on this foundation, we sought to determine whether deleting CA4 or...

Creatine is an important regulator of brain bioenergetics, yet the efficacy of creatine supplementation (CrS) in the brain remains largely unknown. Measurement of brain creatine using proton (¹H) and phosphorus (³¹P) magnetic resonance spectroscopy is highly sensitive to voxel placement, signal quality, analysis pipelines, and reporting conventions which can obscure the detection of biological responses to CrS. There is evidence that CrS increases brain creatine, but this response may be dose...

CONCLUSIONS: The provision of Igf1 specifically from placenta is critical for offspring forebrain development. This temporary early deficit has persistent sex-specific neurobehavioral effects. These outcomes have relevance for autism risk and highlight mechanisms that could facilitate intervention development for adverse outcomes after early loss of placental hormone support in perinatal adversity.

Despite age-related declines in the structure and function of auditory and language-related regions, many older adults retain a relatively preserved ability to understand speech in noisy environments. However, the neural mechanisms supporting this ability remain unclear. In this study, 30 older adults (59-71 years) with normal hearing listened to narratives spoken by a separate group of speakers at varying noise levels, with their neural activity recorded using functional near-infrared...

Previous reports suggest that the progression from subacute to chronic non-specific low back pain (nsLBP) involves functional changes in both the nervous and immune systems. The purpose of the present study was to characterize the gene expression profiles of circulating immune cells that affect the interaction between these two systems when subacute nsLBP turns into chronic nsLBP. Participants aged 18-55 were included based on the presence or duration of LBP, with peripheral blood mononuclear...

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CONCLUSIONS: This study defines the clinical symptoms of CTNND2-related neurodevelopmental disorders, outlining a recognizable yet variable phenotype that overlaps with other forms of intellectual disability and autism. Our findings provide preliminary evidence of genotype-phenotype correlations and highlight δ-catenin's critical role in modulating WNT signaling during early neural development. These insights advance our understanding of CTNND2-associated disorders and support the importance of...