ObjectiveTo investigate the behavioral outcomes of children with clefts and the psychosocial impact and mental health experiences of their caregivers regarding unintended outcomes of genomic sequencing, that is, secondary genetic findings (SFs).DesignConvergent parallel mixed methods.SettingThe cleft and immunization clinics at the Lagos University Teaching, Hospital, Nigeria.ParticipantsIn total, 127 cases and 158 control caregiver child dyads (quantitative) and 22 caregivers of children with...

Prior cross-sectional studies revealed that multiple chronic conditions (MCC) and polypharmacy are associated with cognitive impairment. The purpose of this study was to determine whether the number of chronic conditions and the number of medications are associated with longitudinal changes in cognition (memory, attention/working memory, semantic ability/language, processing speed, executive function). We analyzed data from 5671 individuals (age 71.4 ± 9.3, 68 % female) from the National...

CONCLUSIONS: Veterans reported interest in coordinated treatment for CP + PTSD; however, the provision of CP + PTSD care provided across different service lines may pose challenges to optimizing care coordination.

Pediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this exploratory analysis, we identified a cohort of pediatric (age <21) patients with evidence of Long COVID and no pre-existing complex chronic conditions using electronic health record data from 38 institutions and used an unsupervised machine learning-based approach to identify subphenotypes. Our method,...

INTRODUCTION: Deep brain stimulation (DBS) is a promising treatment for refractory depression, utilizing surgically implanted electrodes to stimulate specific anatomical targets within the brain. However, limitations of patient-reported and clinician-administered mood assessments pose obstacles in evaluating DBS treatment efficacy. In this study, we investigated whether an affective bias task, which leverages the inherent negative interpretation bias seen in individuals with depression, could...

CONCLUSIONS: Fostering COE-coalition partnerships created opportunities to leverage synergies and build capacity for engagement across multiple domains, contributing to enhanced trust and implementation of interventions across the cancer continuum. The findings provide examples and lessons about synergistic opportunities for cancer centers and coalitions to capitalize on. Successful collaborative relationships were based on identifying shared goals and complimentary expertise and roles, sharing...

Lithium has long been the primary treatment for bipolar disorder and shows promise for managing other neurological and psychiatric conditions. We previously identified the Lithium-inducible SLC6 transporter (List) in Drosophila melanogaster as a gene significantly upregulated in response to lithium chloride supplementation. List encodes a putative amino acid transporter belonging to the Na⁺-dependent solute carrier family 6. Here, we show that List is expressed in the Malpighian tubules, glia,...

CONCLUSION: These findings highlight that even incomplete DAA treatment, alongside OAMT, yields significant cognitive benefits, underscoring the importance of integrated care.

INTRODUCTION: Formal Thought Disorder (FTD) is a significant clinical feature of early-onset psychosis, often associated with poorer outcomes. Current diagnostic methods rely on clinical assessment, which can be subjective and time-consuming. This study aimed to investigate the potential of neuropsychological tests and machine learning to differentiate individuals with and without FTD.

BACKGROUND: Cognitive decline in older adults affects key functions such as memory, concentration, planning, reasoning, and decision-making (DM). This decline in cognitive abilities compromises basic DM skills, with growing evidence that DM can decline before noticeable impairment or an official cognitive impairment diagnosis, adversely impacting quality of life and leading to negative outcomes in financial management and daily activities.

CONCLUSIONS: ProSAAF mitigated some of the harmful effects of substance use on accelerated aging among Black couples, particularly among those with lower preintervention relationship satisfaction. These findings highlight the potential for relationship interventions to serve as sources of constructed resilience that promote healthier aging. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Post-operative delirium (POD) is a common complication after surgery especially in elderly patients, characterized by acute disturbances in consciousness and cognition, which negatively impacts long-term outcomes. Effective treatments remain elusive due to the unclear pathophysiology of POD. To address the knowledge gap, we investigated DNA methylation profiles and gene expression changes in brain cells from POD and non-POD patients who underwent brain resection surgery for medication refractory...

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CONCLUSIONS: We present a theory of change and study design to assess the impact of a novel and patient-centered mobile app to support the SBIRT approach to SUD in primary care settings.

Non-rapid eye movement sleep (NREM) oscillations are critical for cognitive and affective processing. While several studies link anxiety and depression symptoms to sleep quality, a critical gap remains in elucidating the role of NREM physiology in sleep-dependent processing of affect and anxiety symptoms. The goals of the present study were to investigate sleep-dependent consolidation of emotional memory and the relations of NREM oscillations with state anxiety and affect upon awakening in a...