CONCLUSIONS: RTW at 6 months post GBM Surgery corelates with improved mOS. Female sex and lower post-operative KPS scores were the strongest predictors of reduced RTW.

Identifying lesion sites associated with central poststroke pain (CPSP) may facilitate targeted screening for early symptoms, possibly even paving the way for preventive measures and earlier treatment initiation. Here, we test the hypothesis that damage to a nociceptive pathway extending from the brainstem to the cerebral cortex, and including white matter tracts, is associated with CPSP. We investigated the lesion locations of 72 patients with CPSP relative to poststroke comparison subjects...

Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major...

CONCLUSIONS: Breakdowns occur when Veterans are unsure of their providers' rationale and our data underscore the importance of clear communication in establishing trust and optimizing care for Veterans with PTSD and chronic pain. As the interplay between chronic pain and PTSD symptoms takes centerstage in clinical innovations, providers must consider how best to educate their patients and explain their rationale for recommendations. Trauma-informed strategies may be especially valuable for...

CONCLUSIONS: The rural gap in continuity of specialty pain clinic services for veterans has improved across time, particularly in relation to pain clinic psychology visits.

CONCLUSIONS: Three automated pipelines, especially aRFF-B, enabled time-efficient RFF analysis of large continuous speech data sets without manual intervention. This advancement can facilitate large-scale studies using RFF applied to continuous speech, potentially expanding its application in voice research and clinical practice.

CONCLUSION: Our findings can inform future curriculum review and development, ensuring DCPs integrate TIC effectively to enhance care for trauma-exposed patients.

CONCLUSION: This MAT walk-in clinic is the only RAAM-style clinic offering same-day dual-diagnosis medication management in the state of Iowa. The walk-in structure was a key facilitator for patients accessing initial care. Expanding RAAM models in rural areas and incorporating telehealth may help address proximity barriers reported by patients.

CONCLUSIONS: The revised scale is recommended as a replacement for the original ADS since it includes ratings for more drugs and was significantly, albeit weakly, associated with cSAA, similar to previous findings using the original ADS.

BACKGROUND AND OBJECTIVES: Huntington disease is a rare neurodegenerative disorder with no disease-modifying therapies. This study aimed to quantify longitudinal changes in Unified Huntington's Disease Rating Scale (UHDRS) scores and evaluate their susceptibility to placebo response, enhancing our understanding of disease progression and ability to optimize future trials.

CONCLUSIONS: Our analysis supports the utility of NSD-ISS in defining the stages of disease progression, at least in the early clinical and prodromal stages (2B, 3, or 4), suggesting the value of NSD-ISS as a potential research tool for drug development. Further research involving preclinical cohorts is a crucial next step. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)-guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a change to standard prescribing), the use of cautionary medications (i.e., those associated with an actionable PGx genotype), polypharmacy (i.e., ≥ 5...

Randomized clinical trials have resulted in few approved therapies for the treatment of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urologic chronic pelvic pain syndrome. Heterogenous patient populations, mismatches of treatments to patient phenotypes, non-specific outcomes and use of standard study designs not leveraging phenotypic heterogeneity might have contributed to the inability of previous trials to...

CONCLUSIONS: Sex, age, size of social networks, and speech recognition ability are associated with CI users' auditory lifestyle. This research highlights the significance of taking into account the demographics and social network characteristics of adult CI users when assessing the auditory environments they experience in their daily lives.

Developing effective resources to support dementia caregivers requires collaboration between public health officials and those with lived experience of caregiving. This perspective highlights why this collaboration is so crucial to elevating public health practice and describes the unique efforts of the BOLD Public Health Center of Excellence on Dementia Caregiving to foster this collaboration through its Lived Experience Advisory Groups (LEAG). The LEAGs convene people living with dementia,...