CONCLUSIONS: High and immune stress affected adult striatal-dependent behavior, exceeding the threshold necessary for persistent impacts mostly in males, but all stress models affected embryonic microglia, suggesting a lower threshold for early neuroimmune impacts. Distinct severities and aspects of prenatal stress may therefore underlie different NDD-relevant outcomes.

In this study, we reduced the DSM-5 to its constituent symptoms and reorganized them based on patterns of covariation in individuals' (n = 14,762) self-reported experiences of the symptoms to form an empirically derived hierarchical framework of clinical phenomena. Specifically, we used the points of agreement among hierarchical principal components analyses and hierarchical clustering, as well as between the randomly split primary (n = 11,762) and hold-out (n = 3,000) samples, to identify the...

INTRODUCTION: Considerable evidence exists for reduced electrodermal reactivity to aversive cues/events in high-psychopathic individuals, but most research of this kind has employed adult samples and cross-sectional designs. The current study examined skin conductance (SC) activation during anticipation of and in response to a noise stressor in a sample of 9-10 year old children in relation to constituent traits of psychopathy described by the triarchic model (i.e., boldness, disinhibition,...

CONCLUSIONS: The DEI curriculum integrated into the University of Minnesota third-year psychiatry clerkship was well received by students, with positive feedback about the curriculum and an increased ability to work with psychiatric patients from diverse backgrounds.

CONCLUSIONS: Findings highlight the robust connection between race and pain. They also suggest that socioeconomic and rural and pain disparities may be less prevalent in Veterans. Resilience may be a modifiable factor that can improve pain outcomes in Black patients. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

CONCLUSIONS: Findings point to the need to shift care for Veterans with GWI, and similar conditions, away from overly focusing on individual symptoms. Instead, primary care clinicians need training and support, potentially from tertiary care experts, to develop and implement holistic care plans that recognize GWI as a complex chronic condition.

CONCLUSIONS: SVT-MH use among women veterans increased substantially during the study period, with rural-urban gaps narrowing over time. These findings suggest SVT-MH differences may shift rapidly based on infrastructure, outreach, and policy implementation. Ongoing monitoring and tailored strategies are needed to ensure fair access to SVT-MH for all veterans, especially for AIAN and rural women veterans.

CONCLUSIONS: The legal doctrine of settled insanity does not map well onto clinical reality and complicates the intersection of intoxication and mental illness by prompting insoluble questions about the etiology of mental illness. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

CONCLUSIONS: These findings support the potential for TAAR1 agonists as novel treatments for hyperactivity and risky decision-making in BD, and suggest an inverted U-shaped relationship between dopamine tone and decision-making optimization.

CONCLUSION: In this sample of older adults with self-reported mental health condition, about one-third had at least one annual preventive dental visit during the observation period. Receiving care from faculty members was significantly associated with increased odds of attending annual preventive dental visits.

It is hypothesised that structural brain abnormalities in individuals with schizophrenia are associated with aggressive behaviour, but this has not been tested directly. We pooled magnetic resonance imaging and clinical data from 2095 patients and 2861 healthy control subjects across 20 sites of the ENIGMA-Schizophrenia Working Group. Using normative modelling, we quantified individual-level deviations from controls (z-scores) for global and regional grey matter volume and white matter...

CONCLUSION: In all, 30% of patients with UCPPS demonstrated improvement in pain and/or urinary symptoms over 3 years. Baseline factors associated with improvement may represent markers of a milder or localised phenotype and/or treatment effects.

Cognitive symptoms are common in Parkinson's disease (PD) and have debilitating effects on quality of life and disease trajectory; however, the underlying brain mechanisms remain poorly understood. To address this gap, we investigated the relationship between functional connectivity and cognition at multiple time points using longitudinal functional MRI (fMRI) and cognitive assessments from the Parkinson's Progression Marker Initiative (PPMI). We calculated resting-state functional connectivity...

The persistence of HIV latent reservoir is the major challenge to HIV cure because latent viruses serve as sources for viral rebound upon ART cessation. Mechanisms regulating viral persistence are not well understood; thus, there is a compelling need for research focusing on addressing the knowledge gap related to HIV persistence. The present study focuses on the effect of extracellular condensates (ECs) on latent HIV/SIV reactivation in the brain in the context of HIV infection using the...

Cognitive deficits are common in primates, particularly in memory and emotional processes. Rhesus monkey (Macaca mulatta), widely used in cognitive and behavioral research, are central to memory studies. The relationship between recognition memory performance and pupillary dynamics in rhesus monkeys remains underexplored. This study investigated pupil dynamics during recognition memory tasks and their physiological correlates in five sexually mature male rhesus monkeys. We measured pupil...