The creation and ongoing development of the myPPMI platform (see Stanley et al in this issue), has enabled the Parkinson's Progression Markers Initiative (PPMI) to expand our research efforts to acquire additional data, engage a large number of participants, and reduce participant burden to enable long-term follow-up. We now review specific virtual and remote studies and sub-studies including Found, PPMI Online, and PPMI Cognitive that PPMI has developed to enhance participant engagement and...

CONCLUSION: Suicide attempt may be linked to heightened feedback sensitivity to environmental contingencies, greater decision-making randomness and higher rumination. Moreover, the role of both forgetfulness and deck perseverance in trauma survivors at risk for suicide needs to be further investigated to refine their cognitive profile.

Photometry and electrophysiology are powerful tools for investigating brain-behavior relationships. Combining these techniques in freely moving animals would allow us to ask questions such as how neuromodulators impact neuronal firing rates during behavior. Current options are limited-requiring a substantial loss in data quality or restricting naturalistic movement. These drawbacks arise from engineering limits on devices that allow optically tethered subjects to move freely. Here we introduce a...

BACKGROUND: Patients with extensive ischaemic change are often excluded from endovascular thrombectomy. We aimed to synthesise the evidence from recent trials in these patients by performing a systematic review and individual patient data meta-analysis to estimate treatment benefit, including within clinical and imaging subgroups.

Transcranial magnetic stimulation (TMS) is a widely used neuromodulation treatment for depression, but its mechanisms are poorly understood. Indirect clinical evidence suggests that TMS enhances plasticity within the prefrontal cortical target site and engages downstream networks. However, establishing causal mechanisms to help optimize the large stimulation parameter space has been challenging. Using an optogenetic model of accelerated intermittent theta burst stimulation (prelimbic [PL]-aiTBS)...

CONCLUSIONS: This early report highlights the value of a human-centered, iterative process for adapting therapeutic materials for digital delivery in SUD treatment. Although the modules performed well overall on PEMAT-P benchmarks, actionability was less consistent than understandability, and aggregate scores masked weaknesses in several individual modules. This indicates that a standardized process does not guarantee actionable material across all content types. Involving current patients in...

Physical inactivity constitutes a pressing societal problem. To realize physical activity's (PA) potential as a key health resource, mechanisms of PA engagement need to be understood. Laboratory and interventional studies documented that exercise relates to affective well-being (AWB) and suggested that AWB may shape PA behaviour. Digitalization enabled the investigation of how PA relates to AWB in everyday life, but findings from individual studies are ambiguous. Here we compiled 67 datasets...

Neuroimaging plays a critical role in the diagnosis of Alzheimer's disease (AD), with Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) providing detailed structural and functional information for deep learning (DL) based classification. However, their high cost and limited availability restrict widespread clinical use. Computed Tomography (CT), while affordable and widely accessible, is diagnostically insufficient for detecting subtle neurodegenerative changes associated...

BACKGROUND: Previous studies showed impaired decision-making in suicide attempters, but the cognitive mechanisms in play and subgroup differences among attempters need further research. Understanding these differences is crucial for developing targeted interventions.

INTRODUCTION: Inbred mouse strains are essential to biomedical research, yet accumulating mutations and substrain divergence introduce phenotypic variability that can confound experimental outcomes. This study investigates behavioral differences among 13 inbred mouse substrains: eight C57BL/6 (B6) and five C57BL/10 (B10), bred in-house to control for environmental effects.

The collection of electroencephalography (EEG) data in neonates typically occurs during sleep. EEG activity is highly sleep-state dependent, therefore differentiating between states during data processing can provide important insights into neurodevelopment. Despite this, there have been a paucity of studies directly comparing how infant EEG data, especially event-related potentials, differ between these sleep states. Here, we adapted the Maryland Analysis of Developmental EEG pipeline (MADE) to...

INTRODUCTION: Despite efforts to curtail prescribing, prescribing opioids remains common. With the impacts of the United States opioid epidemic continuing to multiply, effective and acceptable alternatives to opioids (and reduce opioid use) are needed. The Illinois' Opioid Alternative Patient Program (OAPP) is a novel program developed and implemented specifically to increase access to cannabis as an alternative to opioids. The current study aimed to: (1) characterize early adopters' attitudes...

Pain treatments have modest effects. Health outcomes might be improved if treatments are matched to mechanisms underlying the persistence and biopsychosocial impact of an individual's pain. The International Association for the Study of Pain (IASP) defines 3 mechanistic pain descriptors presumed to involve different mechanisms-nociceptive, neuropathic, and nociplastic. Although treatments to address each descriptor have been proposed, there is no consensus on how to assign descriptors to...

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