Sex and gender are important variables in research, but they are inconsistently explored. The international PAINDIFF Network makes 13 recommendations for studying sex and gender as variables in pain research, which are applicable across the spectrum of biopsychosocial research. Five universal recommendations apply to the majority of research studies: (1) include males and females as standard practice, (2) account for sex in randomization or counterbalancing and testing order, (3) power for sex...

Early-onset psychosis presents diagnostic challenges due to overlapping clinical presentations and complex comorbidities, typically requiring specialized tertiary care with extensive neuroimaging, neuropsychometric testing, and multidisciplinary evaluation. This case-control study investigated whether machine learning could integrate multiple diagnostic modalities to create an objective diagnostic framework for early-onset psychosis. We recruited 45 patients with early-onset psychosis and 34...

CONCLUSIONS: Acute measures of cognition, including g, can predict functional independence 12 months after stroke. g and visuospatial ability measures were the most robust predictors.

Transcranial magnetic stimulation combined with intracranial EEG (TMS-iEEG) has emerged as a powerful approach for probing the causal organization and dynamics of the human brain. Despite its promise, the presence of TMS-induced artifacts poses significant challenges for accurately characterizing and interpreting evoked neural responses. In this study, we present a practical preprocessing pipeline for single pulse TMS-iEEG data, incorporating key steps of re-referencing, filtering, artifact...

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CONCLUSIONS: Equations using WC and BRI perform better for estimating CRF than equations using body mass index and resting heart rate in an inactive older adult population. These equations could be used to screen participants during study enrollment when specific estimates of CRF are desired for the study sample. However, these equations should be validated for use in clinical populations to stratify disease risk.

Background/Objectives: This systematic review summarizes the evidence regarding potential mechanisms underlying the relationship between spiritual practices and cognitive health in adults. The review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Methods: An extensive search of six electronic databases (i.e., PubMed, PsycINFO, Embase, Sociological Abstracts, ATLA, CINAHL) was conducted using keywords related to spiritual...

CONCLUSIONS: The observed developmental changes in traditional and computational metrics are largely consistent with the optimization of learning from rewards across adolescence. Further, the observed developmental changes in specifically reward-related computational parameters are consistent with heightened adolescent reward system plasticity. Additionally, there was support for our hypothesis that maternal history of depression may exert a unique effect on learning from rewards specifically,...

CONCLUSIONS: High and immune stress affected adult striatal-dependent behavior, exceeding the threshold necessary for persistent impacts mostly in males, but all stress models affected embryonic microglia, suggesting a lower threshold for early neuroimmune impacts. Distinct severities and aspects of prenatal stress may therefore underlie different NDD-relevant outcomes.

In this study, we reduced the DSM-5 to its constituent symptoms and reorganized them based on patterns of covariation in individuals' (n = 14,762) self-reported experiences of the symptoms to form an empirically derived hierarchical framework of clinical phenomena. Specifically, we used the points of agreement among hierarchical principal components analyses and hierarchical clustering, as well as between the randomly split primary (n = 11,762) and hold-out (n = 3,000) samples, to identify the...

INTRODUCTION: Considerable evidence exists for reduced electrodermal reactivity to aversive cues/events in high-psychopathic individuals, but most research of this kind has employed adult samples and cross-sectional designs. The current study examined skin conductance (SC) activation during anticipation of and in response to a noise stressor in a sample of 9-10 year old children in relation to constituent traits of psychopathy described by the triarchic model (i.e., boldness, disinhibition,...

CONCLUSIONS: The DEI curriculum integrated into the University of Minnesota third-year psychiatry clerkship was well received by students, with positive feedback about the curriculum and an increased ability to work with psychiatric patients from diverse backgrounds.

Lesion-deficit mapping is a premier technique for dissociating neural correlates of cognitive functions. However, the contribution of domain-general cognition (g) to the performance of virtually all complex behavioral tasks may encumber such efforts. This possibility has been largely unexplored. Here, we examined the influence of g in lesion-deficit mapping using a combination of structural equation modeling, lesion-behavior mapping (LBM), and structural (sLNM) and functional (fLNM) lesion...

Human lesion studies offer one of the most direct routes to investigating the causal relations between brain regions and behavioral outcomes in circumstances where experimental interventions are highly restricted. However, these studies face a major challenge in identifying the right level of granularity at which brain regions and behavioral outcomes should be analyzed to identify the association between lesions to specific brain regions and specific behavioral outcomes. Here we showcase a novel...

CONCLUSIONS: Findings highlight the robust connection between race and pain. They also suggest that socioeconomic and rural and pain disparities may be less prevalent in Veterans. Resilience may be a modifiable factor that can improve pain outcomes in Black patients. (PsycInfo Database Record (c) 2025 APA, all rights reserved).