Thalamocortical circuits regulate information flow between sensory inputs and higher-order processing, and their disruption is increasingly implicated in psychotic disorders. However, scalable biomarkers of this circuitry remain limited. We assessed P50 sensory gating, 40 Hz auditory steady-state responses (ASSRs) and sleep spindles in relation to resting-state thalamocortical connectivity in early-course psychosis (EC, n = 19), first-degree relatives (FHR, n = 24), and demographically matched...

CONCLUSIONS: As compared to social overinclusion, Cyberball-induced social exclusion did not significantly influence performance on cognitive tasks associated with suicide risk. Future research may consider within-subject designs comparing exclusion and inclusion paradigms, using alternative acute stress manipulations or powering studies to detect smaller effect sizes when studying interpersonal stress in youth at high-risk for suicide.

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CONCLUSIONS: Group-based interventions may positively impact weight trajectories and cardiometabolic health among adolescent military-dependents. Future studies should elucidate potential moderators and mechanisms of interventions on outcomes in this important population.

Over the past decade, fetal, infant, and toddler (FIT) neuroimaging has become a rapidly expanding field, driven by advances in technology and computational methods. By providing non-invasive ways to explore the developing brain in both typical and pathological development, FIT neuroimaging holds promise for advancing pediatric medicine. Magnetic resonance imaging (MRI), ultrasonography, and electroencephalography (EEG) are regularly used in clinical practice to identify or rule out structural...

Hippocampal activity supports memory and many other brain functions. Transcranial magnetic stimulation (TMS) guided by hippocampal functional connectivity (FC) shows promise in improving memory, but direct neural evidence of its capacity to engage and modulate hippocampal activity is lacking. Here we combined TMS with intracranial electroencephalography (iEEG) in 8 neurosurgical patients and with functional magnetic resonance imaging (fMRI) in 79 neurologically healthy participants. We...

CONCLUSIONS: While the PBA-s demonstrates adequate internal consistency, our results revealed high rates of non-endorsement (i.e., item total scores = 0) and a variable factor structure with disease progression. Thus, the PBA-s may not distinguish mild changes in behavioral symptoms that might occur in early HD-ISS stages of disease.

The utility model offers a framework for ethical stewardship, patient empowerment, and distributed innovation.

CONCLUSION: The NSD-ISS, informed by biological and clinical data, identifies individuals at risk for clinical phenoconversion before clinical diagnoses occur, and its utilization may identify optimal participants for enrollment in disease modifying clinical trials. DAT imaging may serve as an appropriate marker of disease progression in NSD.

The study of cytoskeletal proteins has been limited by some of their intrinsic properties, such as fixed intracellular localization and insolubility, which limit the implementation of many protein-protein interaction assays. Far Western blotting is a powerful biochemical technique used to detect and quantify protein-protein interactions on a membrane, addressing limitations in cytoskeletal research. This method combines traditional Western blotting with protein overlay assays to identify and...

CONCLUSIONS: The results provide preliminary evidence that a structured, PCIT-informed CDI skills practice model can be feasibly implemented by paraprofessionals and is associated with meaningful improvements in caregiver behavior and child behavior outcomes in the first 2-3 months following service initiation. The findings support BSF as a promising workforce-embedded approach and inform future controlled studies examining effectiveness, sustainability, and broader implementation outcomes.

Eating-related disorders such as anorexia nervosa, bulimia nervosa and obesity are associated with high rates of morbidity and mortality in the United States. To investigate the neuroanatomical structures involved in appetite and weight change, we employed lesion symptom mapping. 358 patients with focal brain lesions and appetite ratings were recruited, as well as 48 patients with pre- and post-lesion weight records. Partial least squares regression identified a significant association between...

CONCLUSION: Near-physiologic brain activity may be restored during prolonged CPR if oxygenation thresholds are met and is associated with ROSC. Further research is needed to evaluate survival outcomes.

CONCLUSION: In goals of care conversations with Veterans with cardiopulmonary disease, goals evolved, revealing personalized insights that could shape their treatment plans. Variations in participant readiness and challenges in terminology emerged and progressed within single encounters.

CONCLUSION: Scaled improvement in smoking cessation assistance across accredited cancer programs is feasible and achievable relatively quickly. Findings provide a framework to guide national adoption for smoking cessation assistance as standard care for all patients with newly diagnosed cancer.