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Most Recent PubMed Publications
SNP-associated differential methylation in <em>ARHGEF38</em>: insights into genetic-epigenetic interactions
Friday, May 30, 2025
Emese H C Kovács
CONCLUSIONS: In this small sample size study, differential methylation in ARHGEF38 was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the relevance of considering genetics when interrogating epigenetic mechanisms.
Positive changes in employment status are associated with reduced alcohol use frequency at discharge from outpatient specialty treatment
Friday, May 30, 2025
Nicholas L Bormann
CONCLUSIONS: Findings suggest that improving employment status may be relevant for reducing alcohol use frequency. This aligns with past work showing overall improved health outcomes with lower unemployment levels. Incorporating vocational training and workforce engagement activities into outpatient treatment may help augment traditional approaches to improve an individual's RC.
Reply to: "Use of Robust Norming to Create a Sensitive Cognitive Summary Score in De Novo Parkinson's Disease: An Illustrative Example"
Thursday, May 29, 2025
Daniel Weintraub
No abstract
Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment
Thursday, May 29, 2025
Mirjam Wolfschlag
Dopamine replacement therapy for Parkinson's disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining bilateral striatal injections of 6-hydroxydopamine. Daily treatment with ropinirole (2.5 mg/kg), L-DOPA (24.0 mg/kg), or their combination was given for six weeks while animals were examined using tests of compulsive checking and motor stereotypies...
Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant
Thursday, May 29, 2025
Felix P Mayer
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD), autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity disorder (ADHD). Treatment of these disorders remains inadequate, as exemplified by the therapeutic use of d-amphetamine and methylphenidate for the treatment of ADHD, agents with high abuse liability. In search for an improved and non-addictive therapeutic approach for the treatment of DA-linked disorders, we...
Astrocyte morphogenesis requires self-recognition
Wednesday, May 28, 2025
John H Lee
Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance^(1-4). Clustered protocadherin (cPcdh) proteins, which comprise a large family of isoform-specific homophilic recognition molecules, have a pivotal role in the neuronal self-avoidance that is required for mammalian brain development^(5-7). The probabilistic expression of different cPcdh isoforms confers unique identities on neurons and forms the basis for neuronal processes to...
Psychometric Properties of the Knee Osteoarthritis Pain Index
Monday, May 26, 2025
Scott G Ravyts
CONCLUSIONS: Overall, the psychometric properties of the KOAPI were comparable or better than those produced by the original BPI pain severity subscale. The KOAPI may be a helpful screening and outcome measure for individuals with KOA that more closely captures symptoms which drive patients to seek clinical care.
Integrated multi-omics analysis reveals immunovascular mechanisms of the placenta-maternal brain axis and lifespan neurobehavior changes in a mouse model of preeclampsia
Monday, May 26, 2025
Serena Gumusoglu
Preeclampsia (PE) is a hypertensive disorder of pregnancy, among the leading global drivers of maternal morbidity. PE can precipitate neuropsychiatric risk, including for peripartum anxiety, depression, and cognitive problems. To investigate mechanisms underlying psycho-obstetric risk in PE, we examined maternal metabolic, placental, brain, and behavioral changes in our chronic vasopressin (AVP) infusion PE mouse model (C57Bl6/J). Elevated maternal AVP secretion predicts PE in humans, and...
Self-management for people with epilepsy and a history of negative health events (SMART): A randomized controlled effectiveness trial
Saturday, May 24, 2025
Martha Sajatovic
OBJECTIVES: This 2-site, 6-month randomized controlled trial of an epilepsy self-management (ESM) curriculum (SMART) vs. 6-month waitlist (WL) control assessed effects on epilepsy outcomes in 160 people with epilepsy (PWE).
Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021
Friday, May 23, 2025
GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators
CONCLUSIONS AND RELEVANCE: Although the global age-standardized burden rates of SAH more than halved over the last 3 decades, SAH remained one of the most common cardiovascular and neurological causes of death and disabilities in the world, with increasing absolute case numbers. These findings suggest evidence for the potential health benefits of proactive public health planning and resource allocation toward the prevention of SAH.
The Effect of Clinical Factors on the Reversion of Cg05575921 Methylation in Smoking Cessation
Friday, May 23, 2025
Robert Philibert
CONCLUSIONS: When combined with data from prior studies, these analyses of the long-term reversion of cg05575921 methylation will be informative to those considering FIT approaches to incentivizing reversion of cg05575921 as an index of short- and long-term smoking cessation.
Patterns of Non-Suicidal Self Injury Methods among Korean Youths: Associations with Sociodemographic, Psychosocial, and Clinical Characteristics
Thursday, May 22, 2025
Isak Kim
To identify heterogeneous patterns of non-suicidal self-injury among Korean youths and examine the associations with sociodemographic, psychosocial, and clinical characteristics. We studied 701 Korean youths aged 9 to 24 with a history of NSSI. Using latent class analysis (LCA), we identified NSSI patterns within the sample, employing R3STEP and DU3STEP features to explore predictors and distal outcomes across identified classes. Eight NSSI methods were included as indicators of LCA (e.g.,...
Epigenetic assessments of alcohol consumption predict mortality in smokers at risk for lung cancer in the prostate, lung, colorectal and ovarian cancer screening trial
Thursday, May 22, 2025
Robert Philibert
DNA methylation at cg05575921, an established biomarker for smoking predicts risk for lung cancer (LC). Although heavy alcohol consumption (HAC) frequently accompanies smoking, the relationship of HAC to overall mortality in those at risk for LC is not well known. Determining the contribution of HAC to mortality in those who smoke is important because HAC is also a major driver of mortality and is potentially treatable. To help answer this question, we examined the relationship of epigenetic...
Hybrid Virtual Group Model for Substance Use Disorder Therapy: A Scoping Review
Tuesday, May 20, 2025
Edward A Trimble
CONCLUSION: We propose a consensus definition of hybrid virtual group models where at least one group member, either the facilitator or one of the participants, attends groups in-person while at least one member attends virtually. While research is limited, early findings suggest that hybrid SUD groups have similar outcomes to in-person groups and better outcomes than virtual-only groups. Unique considerations should be made to ensure that hybrid SUD models are implemented appropriately and...
Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America
Tuesday, May 20, 2025
Sabine Naudin
CONCLUSIONS: Findings from this large-scale pooled analysis support a modest positive association between alcohol intake and pancreatic cancer risk, irrespective of sex and smoking status. Associations were particularly evident for baseline alcohol intake of at least 15 g/day in women and 30 g/day in men.